Computational Chemistry
Structure-based drug design
Fragment-based drug design
Generation/screening of virtual libraries
Lead- and scaffold-hoping
Generation of robust and predictive: homology models, pharmacophore models, QSAR models
In silico prediction of ADMET properties
In silico prediction of Mutagenicity / Genotoxicity
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Medicinal Chemistry
Design and synthesis of focused libraries
SAR design
Generating virtual libraries
Hit to lead identification
Structural biology support to guide lead optimization
Lead optimization by managing ADME and safety profiles
IND-candidate selection
Support in IND enabling studies
Identification of CRO partners and program/project management
Prodrug design and strategies
Custom synthesis of impurities for Generic, 505(b)(2) and NDA products
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Pharmacology
In vitro ADME
In vitro biology assays
In vitro toxicity assays
Target engagement and biophysical assays
Molecular biology studies
In vivo DMPK
In vivo efficacy assays
In vivo toxicity studies
In vivo safety pharmacology studies
Impurity qualification by in vitro and in vivo toxicity studies
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Chemistry, Manufacturing and Controls
Process development of NCEs
Route scouting strategies
Pilot synthesis and technology transfer
Complete process optimization and validation
GMP manufacturing
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